Advanced Systems explores defining-edge computing approaches, including adaptive computing systems, distributed systems, and grid and high-performance computing.  

Computational Sciences seeks to solve complex science, engineering and defense problems through novel supercomputing approaches, including computer architecture, VLSI, compilers and other software tools for maximizing high-end systems use.

Computer Networks investigates Internet protocols and architecture, sensor nets, system security and space systems networking.  

Distributed Scalable Systems helps decision-makers understand and envision complex situations, plan for alternative futures, and select between difficult options through research and development on information/simulation integration, human-in-the-loop architectures, resource management decision aids, and systems engineering.

Dynamic Systems applies novel computing architectures and devices -- including tiled multi-core architectures, distributed sensor and reconfigurable networks, and processor-in-memory systems -- to real-time signal processing domains, primarily for federal customers.

Intelligent Systems delves into theoretical and practical aspects of digital government; information agents, systems and integration; knowledge representation, reasoning and capture; interactive education and training; semantic web languages; and adaptive robots.

Medical Information Systems explores the intersection of healthcare and informatics to help transform healthcare discovery, practice and delivery, including Grid computing, information security, service-oriented architectures, and imaging and medical informatics.

Silicon Systems operates the MOSIS integrated circuit (IC) fabrication serice, which pools designs from multiple users to create prototype for relatively low or no cost. Research includes VLSI and MEMS design, analysis and fabrication tools and approaches.